Dynein intermediate chain binding

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August undefined, 2024

WebFeb 11, 2024 · Seventy percent of the world’s internet traffic passes through all of that fiber. That’s why Ashburn is known as Data Center Alley. The Silicon Valley of the east. … WebFeb 5, 2024 · Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2024]

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Web3.5.2 Dynein. Dynein is a large macromolecular complex with a molecular weight of approximately 1.2 MDa. It is composed of heavy intermediate, light intermediate, and light chains. The heavy chains contain the motor domains with six AAA ATPase domains and an MT-binding stalk ( Fig. 2.3; Oiwa and Sakakibara, 2005 ). WebMar 21, 2024 · Dynein will initiate translocation of late endosomes to microtubule minus ends only after interacting with betaIII spectrin, which requires the activities of Rab7 … tsp in military

Dynein - an overview ScienceDirect Topics

Weblecular masses of .400 kDa; intermediate chains (DIC) of 70–80 kDa, some of which have been localized to the dynein tail (4, 5); and several light chains of different molecular … WebDynein axonemal heavy chain 5 is a protein that in humans is encoded by the DNAH5 gene. [5] [6] [7] DNAH5 is a protein-coding gene. 1 It provides the instructions for synthesizing a protein that belongs to a microtubule-associated protein complex made of heavy, light and intermediate chains. 2 DNAH5 is responsible for making the heavy … WebJul 31, 2015 · Furthermore, Gbeta competes with the dynein intermediate chain for binding to Tctex-1, regulating assembly of Tctex-1 into the dynein motor complex. We propose that Tctex-1 is a novel effector of ... tsp in measurement

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Dynein - an overview ScienceDirect Topics

WebCentral to the function of this motor protein complex is dynein intermediate chain (IC), which binds the three dimeric dynein light chains at … WebFeb 6, 2024 · Previous studies have revealed that all tested cargo adaptors bind two subunits of dynein: the light-intermediate chain and the heavy chain [8. Lee I.-G. et al. ... which they designated the ‘heavy chain-binding site 1’ (HBS1) motif. Interestingly, both BICDR1 molecules in the structure use the HBS1 motif to interact with different dynein-A ... tsp in mypayWeb13411 Ensembl ENSG00000105877 ENSMUSG00000018581 UniProt Q96DT5 n/a RefSeq (mRNA) NM_001277115 NM_010060 RefSeq (protein) NP_001264044 n/a Location (UCSC) Chr 7: 21.54 – 21.9 Mb Chr 12: 117.84 – 118.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dynein axonemal heavy chain 11 (DNAH11), is a … t spin off news

"WebCytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein … " - Dynein intermediate chain binding

Dynein intermediate chain binding

Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated …

WebJun 1, 2002 · dynein intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: dynein light intermediate chain binding Source:GO_Central. 1 publication. ... Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. ... WebDec 8, 2024 · Dynein_heavy; Dynein heavy chain and region D6 of dynein motor pfam08393 Location: 763 → 1162 DHC_N2; Dynein heavy chain, N-terminal region 2 pfam12777 Location: 2586 → 2933 MT; Microtubule-binding stalk of dynein motor pfam12781 Location: 2962 → 3178 AAA_9; ATP-binding dynein motor region D5 …

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Webdata:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAKAAAAB4CAYAAAB1ovlvAAAAAXNSR0IArs4c6QAAAw5JREFUeF7t181pWwEUhNFnF+MK1IjXrsJtWVu7HbsNa6VAICGb/EwYPCCOtrrci8774KG76 ... WebSep 27, 2004 · Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in …

Web1 day ago · All light and intermediate chains are present, and only the ODA-DC complex is missing (Rao et al, 2024). ... Step 2: The β-HC, from helical bundle 5 to the β-dynein … WebApr 26, 2024 · Cytoplasmic dynein belongs to the AAA+ superfamily of proteins. 13 There are nine subfamilies of dynein consisting of two cytoplasmic and seven axonemal dyneins. 12 A homodimer that is composed of two heavy chains (DHC, encoded by DYNC1H), two light intermediate chains (DLIC, encoded by DYNC1LI), four intermediate chains …

WebOct 1, 2014 · The LIC domain structure has interesting parallels with the dynein intermediate chain, which has a well-ordered WD repeat domain that interacts with the heavy chain and a less conserved disordered … WebCytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and ...

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WebFeb 5, 2008 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: minus-end-directed microtubule motor activity Source:GO_Central. 1 publication. ... Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. ... phipps reporting tallahassee flWeb1 day ago · All light and intermediate chains are present, and only the ODA-DC complex is missing (Rao et al, 2024). ... Step 2: The β-HC, from helical bundle 5 to the β-dynein head, shifts slightly. The two binding partners LC3 and the α kelch domain move with the β-tail. Step 3: The stalk and MTBD of the α-HC shifts. ... tsp in prologWebMar 27, 2024 · Introduction. Cytoplasmic dynein 1 (dynein) is a microtubule (MT) motor protein complex that is responsible for retrograde transport of cellular cargos such as proteins, RNAs, and organelles 1, 2.Dynein is composed of four subunit classes: the heavy chain (HC), light intermediate chain (LIC), intermediate chain (IC), and light chain … tsp in ouncesEach molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), is a dimer of dimers, containing approximately twelve polypeptide sub… tsp in ounce dryWebMay 1, 2001 · The translocation of dynein along microtubules is the basis for a variety of essential cellular movements. Despite a general domain organization that is found in all the cytoskeletal motors, there are structural features of dynein that set it apart from the other motors. These include a track-binding site that is located at the tip of a long projection, … tsp in ounce wetWebCytoplasmic dynein and dynactin are megadalton-sized multisubunit molecules that function together as a cytoskeletal motor. In the present study, we explore the mechanism of dynein-dynactin binding in vitro and then extend our findings to an in vivo context. Solution binding assays were used to define binding domains in the dynein intermediate chain (IC) and … tsp in ml australiaWebMar 29, 2024 · Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the … tsp in pharmacy