WebAug 30, 2024 · Lentiviral particles encoding CDK12 cDNA or shRNAs were generated as described previously 49. The lentiviruses harboring CDK12 cDNA or shRNAs were used to infect each cell line with 6 μg/ml polybrene (Sigma-Aldrich, St. Louis, MO, USA) in order to establish stable CDK12-overexpressing and CDK12-knockdown cell lines, respectively. … WebAug 3, 2024 · Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to ...
CDK12 Antibody Cell Signaling Technology
WebOct 27, 2024 · Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested extensively as targets for cancer therapy. Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase which … WebMar 31, 2016 · Cyclin-dependent kinase 12 (CDK12) as a tumor suppressor gene was discovered in The Cancer Genome Atlas (TCGA) study of high-grade serous ovarian carcinoma (HGS-OvCa; ref. 1).It appeared among the 10 most recurrently mutated genes in HGS-OvCa, which, besides CDK12, included TP53, BRCA1, BRCA2, NF1, and … grand strand mall directory
CDK12 Defects Are an Indicator for the Effectiveness of PARP Inhibitors ...
WebFeb 11, 2024 · Cervical cancer (CC) is a commonly diagnosed and primary consideration of cancer patient death in female reproductive system malignancy. Cyclin-dependent kinase 12 (CDK12), as a transcription-associated CDK, plays important roles in tumor-promoting behaviors, whereas the underlying mechanisms of CDK12 in CC progression are … WebAug 6, 2024 · Background: The aims of this study were to investigate the expression pattern of CDK12 protein in gastric cancer, and to analyze the correlations of CDK12 expression between CD8 + cell density and CCL12 expression. Methods: Eighty-six paired tumor and non-tumor samples were collected from patients who underwent radical surgery and had … WebMay 25, 2024 · Additional in vitro kinase experiments using fly CDK12 5 and human CDK12 from other groups 3,4 also showed that CDK12 effectively phosphorylated the CTD, confirming that CDK12 was a bona fide CTD ... grand strand mall hours