Cisplatin electrolyte

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WebElectrolyte disturbances were observed after several days of cisplatin administration including changes in levels of sodium, potassium, phosphorus, calcium, and chloride. Clinical observations also identified CP toxicity. WebMay 24, 2006 · Conclusion: Cisplatin can cause permanent nephrotoxicity, including Gitelman-like syndrome. This drug should be considered among the possible causes of chronic unexplained electrolyte disorders. Publication types Case Reports Review MeSH terms Adult Alkalosis / chemically induced* Antineoplastic Agents / adverse effects*

Cisplatin nephrotoxicity - PubMed

WebJan 3, 2024 · A variety of kidney diseases and electrolyte disorders can result from the drugs that are used to treat malignant disease, including conventional cytotoxic agents; molecularly targeted agents, which take advantage of molecular abnormalities that drive cancer progression; and immunotherapeutic agents. WebMay 19, 2024 · Electrolyte disorders are also related to cisplatin-induced DNA damage of thiazide-sensitive sodium-chloride co-transporter genes and to the apoptosis of distal tubule cells ( 34 ). Cisplatin treatment may … georgia highway 57

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WebApr 12, 2024 · As previously described, also the cisplatin can induce electrolyte imbalances. In this case, the standard approach to avoid cisplatin-induced nephrotoxicity and the consequent electrolyte alteration is the administration of IV isotonic saline solution in order to stimulate the diuresis. Some authors suggest to add 2 gr of magnesium … WebDec 2, 2014 · Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the … WebCharacterizing the impact of magnesium and potassium-supplemented hydration with cisplatin and the subsequent electrolyte replacement requirements Characterizing the impact of magnesium and potassium-supplemented hydration with cisplatin and the subsequent electrolyte replacement requirements christian lo nigro

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Effect of low-dose prophylactic dopamine on high-dose cisplatin …

WebMay 24, 2006 · Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the … WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium … georgia highway 27WebAs cisplatin treatment is clinically associated with diarrhoea and 5-HT is known to be an intestinal secretagogue,16, 17 we investigated the effect of cisplatin on intestinal fluid … georgia highway 92

"WebThe proteinuria associated with cisplatin nephrotoxicity is attributed to a tubular defect. 32 Hemolytic uremic syndrome has also been described, especially when cisplatin is combined with bleomycin. 33 Sequential … " - Cisplatin electrolyte

Cisplatin electrolyte

Effect of low-dose prophylactic dopamine on high-dose cisplatin …

WebNational Center for Biotechnology Information WebSep 23, 2024 · Cisplatin, a platinum-based antineoplastic agent and a well-known chemotherapeutic drug is the cornerstone for the treatment of many malignancies including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinomas, germ cell tumors, lymphomas, and sarcomas [ 4 ].

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WebSep 27, 2024 · Nausea and Vomiting: cisplatin for injection can cause severe nausea and vomiting. Use highly effective antiemetic premedication [see Dosage and Administration ( 2.1) and Warnings and Precautions ( 5.3 )]. • Myelosuppression: cisplatin for injection can cause severe myelosuppression with fatalities due to infections. WebCisplatin produces moderate to severe nausea and vomiting in virtually all patients. Nausea and vomiting may start within one hour and may persist for more than 24 hours after chemotherapy. Tolerance may improve with 5-day continuous infusion as compared to rapid, intermittent IV administration.

WebApparently not. It was probably due to the treatment. Also, prior to every chemo treatment, I was not only hydrated, but was given a giant bag of electrolytes, with potassium, … WebJan 1, 2015 · Background: Cisplatin, one of the most commonly used chemotherapeutic agents, has electrolyte imbalances as one of its most important adverse effects. We conducted this study to characterize...

WebSep 23, 2024 · Background: Cisplatin is an important drug in the treatment of various Cancers. However, this drug causes nephrotoxicity that is linked to electrolyte … WebFLUID AND ELECTROLYTE 2 Fluid and electrolyte Question one Edema occurs when excessive fluid surrounds the cells of the human body, leading to cellular edema. The fluid may also accumulate in the collagen-mucopolysaccharide, leading to interstitial edema (Cicardi, et al., 2014). Edema is very detriment because it increases the distance of …

WebSep 1, 2024 · Cisplatin for injection, USP, a platinum-based drug for intravenous use, is a white to light yellow lyophilized powder. Each vial of Cisplatin for injection, USP …

WebJul 28, 2024 · Cisplatin is a platinum coordination complex chemotherapy used in the treatment of testicular, ovarian cancer, bladder, and lung cancers, as well as other … georgia highway 82WebFeb 1, 2024 · Serum electrolytes (particularly potassium), CO 2, creatinine and BUN should be determined frequently during the first few months of Lasix therapy and periodically thereafter. Serum and urine electrolyte determinations are particularly important when the patient is vomiting profusely or receiving parenteral fluids. christian long oberbeckWebResults: We observed an increase in serum creatinine level to a peak of 1.9 mg/dL (range, 0.8 to 7.8) in the dopamine group, in comparison to 1.4 mg/dL (range, 0.9 to 3.3) in the placebo group (P = .04). Urinary magnesium excretion increased and EGF excretion decreased in both groups. christian long sleeve shirtWebSep 15, 2024 · Since its approval in 1979 cisplatin has become one of the most extensively used chemotherapeutics in the clinic and although cell resistance and … christian longo death sentence dateWebDrugs & Diseases cisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric … christian long sleeve tee shirtsWebApr 19, 2024 · Cisplatin + etoposide ± doxorubicin ± mitotane Carboplatin + etoposide ± doxorubicin ± mitotane Other recommended regimens Pembrolizumab ± mitotane ... christian long sleeve t shirtsWebApr 15, 2024 · Additionally, cisplatin-induced nephrotoxicity led to the unmasking of a familial form of hypomagnesemia. ... Previously, the baseline electrolyte profile was normal. He was suspected to have nephrotoxicity complicated by acute hypomagnesaemia. Hence, the boy was treated with supplementation and hypomagnesaemia recovered … georgia highway 83