WebBinding assays substantiated that the affinity K d values of four designed cyclic peptides (, , and ) were improved to 23, 67, 42 and 18 μM, respectively, from the 96 μM of linear eILP peptide. Keywords: Chondrocyte senescence; Conformational flexibility; Cyclization; Matrix metallopeptidase 13; Osteoarthritis; Ration peptide design; Self ... WebMar 12, 2024 · Materials & methods: Chondrocyte affinity peptide modified PEGylated polyamidoamine conjugates (CAP-PEG-PAMAM) were prepared and rhodamine B …
Histology, Chondrocytes - StatPearls - NCBI Bookshelf
WebSaid integrin a9β1 ligand has a higher binding affinity with integrin a9β1 than tenascin-C and osteopontin , ... comprising an antibody against osteopontin or fragment peptide portion thereof as an active ingredient. ... promoting chondrocyte differentiation, inhibiting cartilage calcification and inhibiting cartilage degradation, ... WebNov 8, 2024 · Pi et al. identified a short CHP sequence with a high binding affinity toward chondrocytes. They introduced a non-viral vector in which fluorescently labeled chondrocyte-affinity peptide (CAP) was covalently bound to polyethyleneimine (PEI) and injected into rabbit knees to target hyaline cartilage. fulton county ny health department
Cartilage-targeting peptide-modified dual-drug delivery …
WebKeywords: extracellular vesicle, exosome, chondrocyte ... Exosome retention in the articular cavity was improved by fusing a chondrocyte-affinity peptide on the exosome surface. The peptide confined the exosomes to the articular cavity and facilitated exosome penetration into the middle zone of the cartilage tissue to achieve targeted ... WebSep 1, 2024 · Through plasmids transfection, liang et al. (Liang et al., 2024) fused chondrocyte-affinity peptide (CAP) with EV surface protein, and improved the chondrocyte target ability of CAP-EVs. Apart from protein fusion, regulating EV surface charge potential can promote EV penetration since the block influence of negative … WebMay 21, 2024 · Synovial fluid derived MSCs transplantation is an effective method to treat OA cartilage degeneration. kartogenin (KGN) is a small molecule that can induce MSCs to differentiate into chondrocytes in vitro and in vivo. It controls the chondrogenic differentiation of transplanted MSCs. fulton county ny government website