Cenpf cancer

Author: rvsq

August undefined, 2024

WebFeb 24, 2024 · Centromere protein F (CENPF), a member of centromere proteins and a transient kinetochore protein, regulates various cellular processes such as cell migration and mitosis, and its upregulation has been observed in multiple types of cancer, including breast cancer and gastric cancer. WebJan 1, 2024 · CENPF is identified upregulation in pancreatic cancer by genomics profile. • High expression of CENPF is correlated with poor prognosis of patients. • Silencing CENPF significantly inhibited PC cell proliferation, migration and EMT. • Silencing CENPF caused cell cycle arrest and tumorigenicity of pancreatic cells.

Frontiers A Novel Prognostic Signature for Survival Prediction and ...

WebHepatocellular carcinoma (HCC) is one of the deadliest cancer types worldwide. The centromere proteins (CENPs) are critical for the mitosis-related protein complex and are … WebApr 10, 2024 · In particular, CENPF overexpression is significantly associated with tumor metastasis and poor prognosis of hepatocellular carcinoma or breast cancer patients … theory deadman songs

CENPF centromere protein F - NIH Genetic Testing Registry …

WebCENPF(KO) cells had reduced global bio-energetic capacity, acetyl-CoA production, histone acetylation, and lipid metabolism, suggesting that CENPF is a critical regulator of cancer … WebOct 11, 2024 · Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer Abstract. Centromere Protein F (CENPF) associates with the centromere–kinetochore complex and influences cell... Background. Breast cancer (BC) … theory deduction

CENPF promotes the proliferation of renal cell carcinoma

Expression Levels of Three Key Genes CCNB1, CDC20, and CENPF …

WebFeb 5, 2024 · CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle The result points out that CENPF is significantly overexpressed in ACC patients. The overexpressed CENPF predicts a poor prognosis of ACC and might augment the progress of ACC. WebBy searching GEO and TCGA database, we found that CENPF was upregulated in breast cancer tissues. Through RT-qPCR, CENPF was found to be upregulated in breast cancer cells. Functional experiments revealed that CENPF had positive effect on the cellular functions, including proliferation, migration and invasion. shrub freeze protectionWebMay 12, 2014 · The two genes— FOXM1 and CENPF —had been previously implicated in cancer, but none of the prior studies suggested that they might work synergistically to cause the most aggressive form of prostate cancer. The study was published today in the online issue of Cancer Cell. shrub fragrant flowers

"WebCentromere protein F is a protein that in humans is encoded by the CENPF gene. [5] [6] [7] It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia. [8] [9] Function [ edit] " - Cenpf cancer

Cenpf cancer

Overexpression of CENPF correlates with poor prognosis and …

WebApr 10, 2024 · In particular, CENPF overexpression is significantly associated with tumor metastasis and poor prognosis of hepatocellular carcinoma or breast cancer patients [15,16]. In addition, CENPF was also found to be remarkably upregulated in pancreatic cancer, non-small cell lung cancer and papillary thyroid cancer and is commonly … WebJan 24, 2024 · Based on these genes, we constructed and validated a 5-gene prognostic signature (including ACADM, CENPF, KDELC1, PLOD2, and TRMT1) to distinguish low- and high-risk KIRC patients of poor survival in TCGA and E-MTAB-1980 cohorts.

Did you know?

WebNomogram indicated CENPF clinical predictive value for 1-, 3-, 5-, and 7-year melanoma overall survival. Therefore, CENPF plays a vital role in the progression and … WebFeb 21, 2024 · CENPF was shown to promote the proliferation and migration of HCC cells 16 and accelerate bone metastasis of breast cancer. 21 Additionally, CENPF …

WebCENPF, CENPE, CENPU, CENPA, and CENPM were the most commonly reported CENPs in breast cancer datasets. Figure 2 The mRNA expression levels of CENPs in different … WebJan 31, 2024 · CENPF has been found to be overexpressed in various malignant tumours, such as prostate cancer, breast cancer, and nasopharyngeal carcinoma, and to activate …

WebSep 30, 2024 · Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a low 5-year survival rate. The heterogeneity of HCC makes monotherapy unlikely. The development of diagnostic programs and new treatments targeting common genetic events in the carcinogenic process are providing further insights into the … WebMay 12, 2014 · Experimental validation shows that FOXM1 and CENPF function synergistically to promote tumor growth by coordinated regulation of target gene expression and activation of key signaling pathways associated with prostate cancer malignancy. Furthermore, co-expression of FOXM1 and CENPF is a robust prognostic indicator of …

WebFeb 5, 2024 · The expression peak of CENPF is in the cell cycle of the G2/M phase. The aberrant expression of CENPF has been found in multiple malignancies, including …

WebProduct name Anti-CENPF antibody See all CENPF primary antibodies Description Rabbit polyclonal to CENPF Host species Rabbit Tested applications Suitable for: IHC-P more details Species reactivity Reacts with: Human Predicted to work with: Chimpanzee, Gorilla, Orangutan Immunogen Synthetic peptide: shrub for full sun ukWebFeb 28, 2024 · • CENPF is a potential oncogene and prognostic marker in RCC, which can be used as an independent prognostic factor. Introduction Other Section Renal cell carcinoma (RCC) is the ninth most common cancer worldwide. It is estimated that there were more than 337,000 new cases diagnosed in 2012. shrub for privacy screenWebMar 20, 2024 · Among CENP family genes, CENPF and CENPE are mutated at high frequencies in various tumors, while CENPM and CENPA are less frequently mutated. Furthermore, CENPs regulate the tumor mutational burden, stemness, and microsatellite instability, and are associated with tumor immunity. shrub fragrant white flowersWebFeb 7, 2024 · MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells. Zhou S, Han H, Yang L, Lin HZhou S, et al. BMC Gastroenterol, 2024 Mar 28. … shrub framesWebSep 22, 2024 · The expression of CENPF has been detected in different cancers, however its expression pattern differs among various types of cancer. These diverse observations … theory defined in researchWebOct 6, 2024 · TOP2A and CENPF are a synergistic pair of MRs that are overexpressed and activated in CC. Their high expression is correlated with some prognosis features (e.g. metastasis) and molecular features (e.g. somatic mutations) and distinctly high in CC vs. many other cancer types. They may be good biomarkers and anticancer drug targets for … theory definition oxford english dictionaryWebExpression of CENPF (hcp-1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... To access cancer specific RNA and … theory decision making